Endocrine Abstracts

A 27 year old woman was examined in 1977 because of amenorrhea andhirsutism. Hormonal evaluation revealed elevated levels of gonadotrophins simoultaneously with biochemical and clinical hyperandrogenism. Cytogenetic evaluation confirmed presence of male karyotype (46XY) and Swyer syndrome (pure gonadal dysgenesis) was diagnosed. Patient underwent laparotomy, however no gonadal tissue was found during this procedure. A few years later molecular genetic evaluation...

Bisphenol A (BPA) is an environmental estrogen found in plastic material such as bottles, food package, dental material, etc. It is known to have many negative effects on human health and its exposure is associated with endocrine disorders including polycystic ovary syndrome (PCOS). Some studies found significantly higher serum and urinary levels of BPA in PCOS women, however its association with steroid hormones is still controversial.Aim: The aim of th...

Objective: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder characterised by menstrual dysfunction, infertility, presence of polycystic ovaries and biochemical and clinical hyperandrogenism affecting up to 4–18% women of reproductive age. Vitamin D is thought to influence the development of PCOS through gene transcription and hormonal modulation of insulin metabolism and fertility regulation. The aim of this prospective case–control study was to...

Objectives: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women. Its increasing prevalence is probably related to environmental estrogens exposure, such as bisphenol A (BPA). BPA is considered to play an important role in the ethiopathogenesis of PCOS and can be responsible for various clinical symptoms. Aim of the study was to compare the levels of urinary BPA between PCOS women and healthy controls and to assess the relationship of BPA to sex...

Background: There is evidence that polycystic ovary syndrome (PCOS) is commonly associated with higher cardiometabolic risk. Aim of the study was to compare various sex streoids in PCOS women with overweight or obesity (BMI >27) and those with lower BMI. Second aim of the study was to determine the relationship of various sexual setroids to cardiovascular risk in PCOS women.Subjects and methods: Study included 64 Caucasian women with PCOS. F...

Objectives: Insulin-like growth factors 1 and 2 (IGF1 and IGF2) are widely expressed mitogenic peptides playing a role in the fetal developement and differentiation. Evidence suggest their possible involvement in the pathogenesis of metabolic syndrome and probably in polycystic ovary syndrome (PCOS).Aim: Aim of the study was to assess the relationship of serum IGF1, IGF2 and IGF binding protein 3 (IGFBP3) levels to steroid hormones and metabolic paramete...